Product ID:CLELAND'S REDUCTACRYL REAGENT, 233157
MSDS Date:02/16/1999
FSC:6505
NIIN:00N092481
Status Code:A
MSDS Number: CJTBX

Emergency Phone: 202-783-7616 (INTERNATL)

Info Phone: 800-854-3417; 619-450-5558

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

(.+-.)-DITHIOTHREITOL; (CLELAND'S REAGENT)

CAS: 27565-41-9

RTECS: XO8576500

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:MAY BE HARMFUL BY INGESTION,
INHALATION OR ABSORPTION THROUGH SKIN. MATERIAL MAY CAUSE
IRRITATION TO THE EYES, SKIN, MUCOUS MEMBRANES, AND THE UPPER
RESPIRATORY TRACT. EXPOSURE TO MATERIAL MAY CAUSE T HE FOLLOWING:
NAUSEA, HEADACHE AND VOMITING.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:SKIN: WASH IMMEDIATELY WITH SOAP AND COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND
WASH BEFORE WEARING. CONSULT MD. EYES: FLUSH IMMEDIATELY WITH
COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE
FLUSHING BY SEPARATING EYELIDS WITH FINGERS. CONSULT MD.
INHALATION: REMOVE TO FRESH AIR AND MONITOR BREATHING. IF BREATHING
BECOMES DIFFICULT , GIVE OXYGEN AND CONSULT MD. IF BREATHING STOPS,
GIVE ARTIFICIAL RESPIRATION AND CONSULT MD. INGESTION: WASH MOUTH
OUT WITH WATER AND CONSULT LOCAL POISON CENTER AND MD.

Flash Point:>110.C, 230.F
Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, ALCOHOL OR
POLYMER FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:EVACUATE AREA. WEAR A NIOSH APPROVED
RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER
GLOVES. SWEEP UP AND PLACE IN A SUITABLE CONTAINER. AVOID RAISING
DUST. HOLD FOR APPROPRIATE DIS POSAL. WASH SPILL SITE AND VENTILATE
AREA AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A (+4C) REFRIGERATOR. DO NOT FREEZE. MATERIAL IS HARMFUL AND AN
IRRITANT. AVOID CONTACT WITH MATERIAL. AVOID PROLONGED OR REPEATED
EXPOSURE. DO NOT BREATHE DUST. AVOID CONTACT WITH SKIN AND EYES.
Other Precautions:IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK
MEDICAL ADVICE IMMEDIATELY. MATERIAL SHOULD ONLY BE HANDLED BY
QUALIFIED, EXPERIENCED PROFESSIONALS.

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES & FULL LENGTH
FACESHIELD .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
WEAR SUITABLE PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING MATERIAL.
Supplemental Safety and Health
MFR'S INFO: MFR'S FAX #: (619) 452-3552. PHYSICAL AND CHEMICAL
PROPERTIES: SOLUBILITY: SOLUBLE IN ETHANOL AND METHANOL.

Solubility in Water:SUPP DATA
Appearance and Odor:SOLID. PACKAGED UNDER AN INERT GAS.

Stability Indicator/Materials to Avoid:YES
AVOID CONTACT WITH BASES, OXIDIZING AGENTS, REDUCING AGENTS, AND ALKALI
METALS.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE, CARBON DIOXIDE, AND SULFUR
OXIDES.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE AND LOCAL REGULATIONS
ARE VARIED AND CHANGE FREQUENTLY. FOR THIS REASON, MFR RECOMMENDS
THAT YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH SERVICES FOR
INFORMATION ON THE DISPOSA L OF THIS PRODUCT OR ARRANGE FOR
DISPOSAL BY A LICENSED DISPOSAL COMPANY.

Toxicological Information:NOTE: TO THE BEST OF MFR'S KNOWLEDGE, THE
TOXICOLOGICAL PROPERTIES OF CLELAND'S REDUCTACRYL REAGENT HAVE NOT
BEEN THORO INVESTIGATED. THE INFO BELOW PERTAINS TO THE PARENT
CMPD, CLELAND'S REAGENT. TOX DATA & REFERENCES: LD50:(IPR,MUS) 169
MG/KG 1972. "JOURNAL OF MEDICINAL CHEMISTRY". 15, 600.
LD50:(IVN,MUS) 94 MG/KG 1972; LD50:(SCU,MUS) 333 MG/KG 1972.
"ARZENEIMITTEL-FORSCHUNG. DRUG RESEARCH". 22, 1434. GENETIC DATA &
REFERENCES: LVR; RAT; DOSE: 1 MMOL/L DNA INHIBITION 1975. "ARCHIVES
OF BIOCHEMISTRY & BIOPHYSICS". 166, 400. REFER TO RTECS FOR
DEFINITION OF ABBREVIATIONS USED IN ABOVE TEST & F OR ADDN INFO.
THIS REPORT(OTHER INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFORMATION AVAILABLE.

Transport Information:UN NUMBER: N/A. PROPER SHIPPING NAME: N/A. IATA
CLASS: N/A. IATA PACKING GROUP: N/A.

Federal Regulatory Information:REGULATORY INFORMATION: XN, XI. RISK
PHRASES: R20/21/22: HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND
IF SWALLOWED. R36/37/38: IRRITATING TO EYES, RESPIRATORY SYSTEM AND
SKIN. SAFETY PHRASES: S22: DO NOT BREATHE DUST. S 24/25: AVOID
CONTACT WITH SKIN AND EYES. S26: IN CASE OF CONTACT WITH EYES,
RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE.
S36/37/39: WEAR SUITABLE PROTECTIVE C LOTHING, GLOVES AND EYE/FACE
PROTECTION. S45: IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK
MEDICA L ADVICE IMMEDIATELY.